OTAVAchemicals, Ltd - synthetic organic compounds for research and drug discovery

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BRD4 Targeted Library

Bromodomain-containing Protein 4 (BRD4)Epigenetic regulators are new popular targets for cancer treatment. One of the promising epigenetic drug targets is Bromodomain-containing Protein 4 (BRD4) that binds to acetylated histone lysine residues and stimulates transcriptional elongation leading to expression of growth-promoting genes. 

General Fragments Library

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The central purpose of this specially designed Fragment Library is to provide

Catalogs & Booklets
This section contains information on current OTAVAchemicals products and services (downloadable files in PDF format).

DOT1L Targeted Library

GPCR focused librariesHistone methyltransferases are promising epigenetic drug targets. Several drugs that inhibit histone methyltransferases have been developed for anticancer therapy. DOT1L histone H3 methyltransferase methylates lysine 79 on histone H3 (H3K79), within the globular histone domain upon which DNA is wrapped.

inhib.jpgOTAVAchemicals offers a number of INHIBITORS and other biologically active compounds modulating activity of distinct macromolecular targets