Inhibitor of IKK kinase
     
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Inhibitor of IKK kinase

5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
potent and selective inhibitor of IKK-? kinase that selectively inhibits IKK-? with an IC50 value of 40 nM and is essentially inactive at IKK-? and IKK-?

Inhibitor_of_IKK_kinase
OTAVAchemicals Catalogue Number: 7020402324
CAS Registry Number: 862812-98-4
Purity: 95%+ (HPLC)


Ref.: Bamborough et al. 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-? kinase. Bioorganic & Medicinal Chemistry Letters (2006), 16, 6236-6240
Abstract: The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-? kinase is described. A 2-thiophenecarbonitrile (CAS RN 862812-98-4) was identified with an IKK-? enzyme potency of pIC50 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.

 
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