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2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid (PAC-1)
OTAVAchemicals Catalogue Number: 7210801533
CAS Registry Number: 315183-21-2
Purity: 95%+ (HPLC)
Ref.: Putt et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nature Chemical Biology (2006), 2, 543-550
Abstract: PAC-1 is the first small molecule known to directly activate procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery.
Wikipedia: http://en.wikipedia.org/wiki/PAC-1
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