Cdk4/6 Inhibitor IV
     
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Cdk4/6 Inhibitor IV

trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol (CINK4)
Cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 M and 5.6 M for Cdk4/D1 and Cdk6/D1, respectively)
Relative stereochemistry

Cdk4-6_Inhibitor_IV
OTAVAchemicals Catalogue Number: 1112092
CAS Registry Number: 359886-84-3
Purity: 95%+ (HPLC)


Ref.: Soni et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. Journal of the National Cancer Institute (2001), 93, 436-446


Abstract: Like p16, the natural inhibitor of Cdk4, CINK4 inhibits Cdk4 activity in vitro and slows tumor growth in vivo.

 
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