PDK1 Inhibitor
     
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PDK1 Inhibitor

2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU03012)
OSU03012 has an IC50 of 5 M for inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1), and therefore Akt activation, with no measurable COX-2 inhibition up to 50 M. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 M across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia (CLL) cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways

PDK1_Inhibitor
OTAVAchemicals Catalogue Number: 7070707053
CAS Registry Number: 742112-33-0
Purity: 95%+ (HPLC)

 
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