ROCK Inhibitor
     
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ROCK Inhibitor

3-(4-(1H-pyrazol-4-yl)-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(3-methoxybenzyl)-1-methylurea

 1225199-26-7

OTAVAchemicals Catalogue Number: 7070707146
CAS Registry Number: 1225199-26-7
Purity: 95%+ (HPLC)


Ref.: Yin, Cameron, Lin, Khan et al Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats. ACS Med. Chem. Lett., 2010, 1 (4), 175179

Abstract: A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.

 
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