Kinesin-like protein 1 Inhibitor
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Kinesin-like protein 1 Inhibitor


Potent inhibitor of Kinesin-like protein 1 with activity in the ATPase assay of 1.70.4 ?M and the MPM-2 cytoblot assay of 0.480.13 ?M.


OTAVAchemicals Catalogue Number:   7112880116

CAS Registry Number: N/A

Purity: 99%

Ref.: A. B. Pinkerton et al. Synthesis and SAR of thiophene containing kinesin spindle protein  (KSP) inhibitors. Bioorg. Med. Chem. Lett. 17 (2007) 35623569.

Abstract: We have identi?ed and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.