Inhibitor of protein kinase CK2 (NHTP33)
     
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Inhibitor of protein kinase CK2 (NHTP33)

3-(5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid

inhibitor of protein kinase CK2, IC50 = 0.008M

NHTP33, inhibitor of protein kinase CK2

OTAVAchemicals Catalogue Number: 1156728

CAS Registry Number: 1216956-54-5

Purity: 95%

 

Ref. 1: Pat. 86041, 2013-12-10. Low-molecular organic ATP-competitive inhibitors of serine/threonine kinase CK2 based on 4-amino-thieno-[2,3-d]pyrimidine heterocycle. Ostrynska O.V., Balanda A., Bdzhola V.G., Kotey I.M. Kharenko P., Yarmoluk S.M.

Ref. 2: Ostrynska OV, Balanda AO, Bdzhola VG, Golub AG, Kotey IM, Kukharenko OP, Gryshchenko AA, Briukhovetska NV, Yarmoluk SM. Design and synthesis of novel protein kinase CK2 inhibitors on the base of 4-aminothieno[2,3-d]pyrimidines. Eur. J. Med. Chem., 2016, 115:148-160
 
Abstract: An extension of our previous research work has resulted in a number of new ATP-competitive CK2 inhibitors that have been identified among 4-aminothieno[2,3-d]pyrimidine derivatives. The most active compounds obtained in the course of the research are 3-(5-p-tolyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5e (NHTP23, IC50 = 0.01 M), 3-(5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5g (NHTP25, IC50 = 0.065M) and 3-(6-methyl-5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5n (NHTP33, IC50 = 0.008M). Structure–activity relationships of the tested 4-aminothieno[2,3-d]pyrimidine derivatives have been studied and their binding mode with ATP-acceptor site of CK2 has been proposed. A negative effect of intramolecular hydrogen bonding in the compounds’ structure is discussed.
 
DOI: 10.1016/j.ejmech.2016.03.004
Price info:
1 MG 40 EUR
5 MG 90 EUR
10 MG 160 EUR
300uL of 10mM solution

60 EUR

 
 
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