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Chemical Optimization
Syntheses of Novel Derivatives of NMDARs Allosteric Modulators

Syntheses of novel allosteric modulators of NMDARsN-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels wich is activated by L-glutamate (the brain’s primary excitatory neurotransmitter). They have many critical roles in CNS function and in various neurological and psychiatric disorders.

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Synthesis of Tetrahydroisoquinoline Derivatives as Perspective Inhibitors of P-glycoprotein 1

Tetrahydroisoquinoline Derivatives as Perspective Inhibitors of P-glycoprotein 1P-glycoprotein 1 (P-gp, Pgp, multidrug resistance protein 1, MDR1, ATP-binding cassette sub-family B member 1, ABCB1, cluster of differentiation 243 or CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity wich evolved as a defense mechanism against harmful substances. But at the same time it pumps many drugs, including anticancer chemotherapeutics, from the cell thereby weakening their action. Consequently, P-gp overexpression is one of the main mechanisms behind decreased intracellular drug accumulation and development of multidrug resistance.

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Synthesis of Barbadin Analogs as Perspective Inhibitors of the ß-Arrestin/ß2-Adaptin Interaction

Analogs of Barbadin as Perspective Inhibitors of the ß-Arrestin/ß2-Adaptin InteractionOur company, OTAVA Ltd., is offering the following chemical optimization service - syntheses of target-specific sets of novel Barbadin analogs for your biological tests. These novel compounds will be selected from a set of 1,000 unique virtual Barbadin analogs using our company’s proprietary molecular modeling platform.

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