OTAVAchemicals, Ltd - synthetic organic compounds for research and drug discovery

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HATs Targeted Library

Histone Acetyltransferase target-focused libraryPost-translational modifications, such as acetylation or phosphorylation, play a crucial role in the regulation of gene transcription in eukaryotes. Different subtypes of histone acetyltransferases (HATs) catalyze the acetylation of histones on specific lysine residues. 

Liver X Receptor Beta Library

Liver X receptor ? (LXR Beta) modulatorsLiver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types.

HDAC Targeted Libraries

GPCR focused librariesClassical histone deacetylases (HDACs classes I, II, and IV) are a promising novel class of epigenetic anti-cancer drug targets. Inhibition of histone deacetylases results in hyperacetylation of histones and modulates gene expression by creating an open chromatin state that leads to expression of previously silenced genes.

DOT1L Targeted Library

GPCR focused librariesHistone methyltransferases are promising epigenetic drug targets. Several drugs that inhibit histone methyltransferases have been developed for anticancer therapy. DOT1L histone H3 methyltransferase methylates lysine 79 on histone H3 (H3K79), within the globular histone domain upon which DNA is wrapped.

inhib.jpgOTAVAchemicals offers a number of INHIBITORS and other biologically active compounds modulating activity of distinct macromolecular targets

Chelator Fragment Library

Chelator Fragments LibraryFragment-based lead design (FBLD) could be used to identify new metal-binding groups for metalloenzyme inhibitors. Several small-molecule chelators have been shown to effectively inhibit metalloproteins, therefore the design,

DNMTs Targeted Libraries

DNMT focused librariesEnzymes involved in the epigenetic regulation of the genome represent promising starting points for therapeutic intervention by small molecules, and DNA methyltransferases (DNMT) are emerging targets for the development of a new class of cancer therapeutics.

BRD4 Targeted Library

Bromodomain-containing Protein 4 (BRD4)Epigenetic regulators are new popular targets for cancer treatment. One of the promising epigenetic drug targets is Bromodomain-containing Protein 4 (BRD4) that binds to acetylated histone lysine residues and stimulates transcriptional elongation leading to expression of growth-promoting genes. 

General Fragments Library

Supplier stockUPDATED! The library has been just updated!
The central purpose of this specially designed Fragment Library is to provide

Catalogs & Booklets
This section contains information on current OTAVAchemicals products and services (downloadable files in PDF format).