Janus Kinase 2 (JAK2)Targeted Library
Janus Kinase 2 (JAK2)Targeted Library
 Janus Kinase 2 (Jak2) focused library
Ligand in JAK2 active site. Docking example from JAK2 Targeted Library.
The detection of H-bonds between ligand and key JAK2 residue (Leu932) was used for the library preparation.
 

In humans, the Janus protein tyrosine kinase family (JAKs) contains four members: JAK1, JAK2, JAK3 and TYK2. JAKs phosphorylate signal transducers and activators of transcription (STATs) simultaneously with other phosphorylations required for activation, and there are several cellular mechanisms in place to inhibit JAK/STAT signaling. That one might be able to modulate selected JAK/STAT-mediated cellular signals by inhibiting JAK kinase activity to effect a positive therapeutic outcome is a tantalizing prospect, as yet incompletely realized. While current data suggest no therapeutic use for JAK1 and TYK2 inhibition, JAK2 inhibition seems a promising but not definitively tested mechanism for treatment of leukemia.

The designed JAK2 Targeted Library comprises only drug-like compounds (PAINS compounds is filtered off). It provides a perfect basis for drug discovery projects related with leukemia.

 

 

All compounds are in stock, cherry-picking is available.

The JAK2 Targeted Library (DB, SD, XLS, PDF format) as well as the price-list is available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain this library or if you need more information.

 

 

 

 

Need more information regarding this product? Send us an inquiry:


Name: *
Company: *


E-mail:
(if you do not receive a response within 24 hours,

please check your email spam folder,

as it may have been blocked by your spam filter)
 *

Please specify name of the product:
*
Word Verification:

 
 
SSL