N-allyl-6-bromo-quinazolin-4-amine

mTOR-independent small molecule enhancer of autophagy

Chemical Formula: C11H10BrN3

Molecular Weight: 264.1

OTAVAchemicals Catalogue Number:  7010010139

CAS Registry Number:  307538-42-7

Purity:  98%

2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide (IQ-1)

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/b-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished b-catenin/p300 interaction and a concomitant increase in b-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.

OTAVAchemicals Catalogue Number: 7070707017

CAS Registry Number: 331001-62-8

Purity: 96% (HPLC)

3-[[6-(3-aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol (TWS119)

Glycogen synthase kinase-3ß (GSK-3ß) inhibitor KD = 126 nM

OTAVAchemicals Catalogue Number: 7070707013

CAS Registry Number: 601514-19-6

Purity: 97%+ (HPLC)

N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

OTAVAchemicals Catalogue Number: 7070707131

CAS Registry Number: 1226056-71-8

Purity: 95%+ (HPLC)