VEGFR inhibitor

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VEGFR inhibitor


7015070102

Cyclin-dependent_Kinase_CDK_Inhibitor

3-[(6,7-Dimethoxy-4-quinazolinyl)amino]-phenol

Inhibitor of IgE-mediated mast cell responses. Tau-Tubulin Kinase 1 inhibitor, phosphorylated TTBK1 KD = 0.46 µM, nonphosphorylated TTBK1 KD = 0.24 µM.

REarranged during Transfection (RET) kinase inhibitor, IC50 = 5 nM, KDR (VEGFR2) kinase inhibitor, IC50 = 66 nM

OTAVAchemicals Catalogue Number: 7015070102

CAS Registry Number: 211555-08-7

Purity: 97% (HPLC)

 

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7070707144

HDAC, EGFR, and HER2 Inhibitor

7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide

Potent multi-acting HDAC, EGFR, and HER2 inhibitor.

HDAC enzyme assay IC50 = 6.5 nM, EGFR = 3.1 nM, HER2 = 19.0 nM

OTAVAchemicals Catalogue Number:  7070707144

CAS Registry Number:  1012054-55-5

Purity:  95%+

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7070707143

Dual VEGFR-2 and tubulin inhibitor

(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(5-{2-[(pyridin-4-ylmethyl)-amino]-phenyl}-[1,3,4]oxadiazol-2-yl)-amine

 Tubulin polymerization inhibitor ITP IC50 =  1.09 µM, G2/M transition block EC50 = 0.009 µM,

VEFGR-2 enzyme IC50 = 0.21 µM, VEGFR-2 cell IC50 = 0.11 µM

OTAVAchemicals Catalogue Number:  7070707143

CAS Registry Number:  830333-53-4

Purity:  95%+

 

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1156353

Inhibitor_of_the_VEGFR-2_and_basic_fibroblast_growth_factor_FGF_kinases3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide (CP-547632)

potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 = 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor ß, and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM

OTAVAchemicals Catalogue Number: 1156353

CAS Registry Number: 252003-65-9

Purity: 95%+ (HPLC)

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1156360

PDGFR_VEGFR_and_FGFR_inhibitor

5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (NSC 702827; SU 6668; TSU 68)

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo.

OTAVAchemicals Catalogue Number: 1156360

CAS Registry Number: 252916-29-3

Purity: 95%+ (HPLC)

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1156358

VEGFR-2_inhibitor

4-((2-((4-Chloro-3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-phenyl)amino)-1,3-benzoxazol-5-yl)oxy)-N-methyl-2-pyridinecarboxamide

IC50 = 28 nM

OTAVAchemicals Catalogue Number: 1156358

CAS Registry Number: 769960-39-6

Purity: 95%+ (HPLC)

 

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7070707147

690206-97-4

4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride (ZM 306416)

OTAVAchemicals Catalogue Number: 7070707147

CAS Registry Number: 690206-97-4

Purity: 95%+ (HPLC)

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1156354

Inhibitor_of_VEGF4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline (AZD2171; Cediranib)

an oral tyrosine kinase inhibitor of all of the VEGF receptors (VEGFR1, VEGFR2, VEGFR3), as well as KIT and (less potently) PDGFRA and PDGFRB

OTAVAchemicals Catalogue Number: 1156354

CAS Registry Number: 288383-20-0

Purity: 95%+ (HPLC)

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1156355

Antagonist_of__VEGFR_EGFRN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine (Vandetanib; ZD6474; Zactima)

selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. It also inhibits RET-tyrosine kinase activity, an important growth driver in certain types of thyroid cancer

OTAVAchemicals Catalogue Number: 1156355

CAS Registry Number: 443913-73-3

Purity: 95%+ (HPLC)

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