The SARS-CoV-2 RNA uridylate‐specific endoribonuclease (non-structural protein 15, NSP15, NSP15/NendoU) is essential in coronavirus biology. It has an RNA endonuclease activity producing 2′‐3′ cyclic phosphodiester and 5′‐hydroxyl termini. Identification of small compounds that specifically target NSP15 is promising for antiviral drug discovery.

The SARS-CoV-2 helicase (non-structural protein 13, NSP13) is essential for coronaviral replication. It separates double-stranded RNA (dsRNA). Identification of small molecules that specifically target replication apparatus has indicated highest potential towards antiviral drug discovery.

The SARS-CoV-2 papain-like protease (PLpro) is a part of NSP3 multi-domain protein. It is essential for coronaviral replication. PLpro has also the additional function - stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Thereby this enzyme is an attractive antiviral drug target.

2′-O-methyltransferase (2′-O-MTase, non-structural protein 16, nsp16) provides the viral mRNA with the ability to camouflage and obscure itself from the host cell, thus preventing recognition and activation of the host immune response which is essential for successful viral infection. Therefore, this protein can act as potential drug target for the SARS-CoV-2.

An outbreak of COVID-19 (coronavirus disease 2019) occurred in Wuhan and it has rapidly spread to almost all parts of the world. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), RNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an important enzyme that catalyzes the replication of RNA from RNA template and is an attractive therapeutic target.

The COVID-19 pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target for this coronavirus is the main protease (3C-like proteinase, 3CL^pro, M^pro) because of its essential role in processing the polyproteins that are translated from the viral RNA.

Machine learning (ML) is advancing various industries, including drug discovery. We applied ML for predicting compounds with anti-SARS activity, which can be used for drug discovery projects related with COVID-19.