ALK5 kinase Inhibitors

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ALK5 kinase Inhibitors


7070707105

Potent and selective ALK5 inhibitors over p38MAP kinase

2-(6-methyl-2-pyridyl)-N-(4-pyridyl)quinazolin-4-amine

Potent and selective ALK5 inhibitors over p38MAP kinase. ALK5 binding IC50 = 0.022 µM,

p38alpha binding IC50 = 6.72 µM, TGF-ß cellular assay IC50 = 0.095 µM 

Chemical Formula: C19H15N5

Molecular Weight: 313.4

OTAVAchemicals Catalogue Number:  7070707105

CAS Registry Number:  733806-89-8

Purity:  97%

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7070707106

CID 9998128

N-(1H-indazol-5-yl)-2-(6-methyl-2-pyridyl)quinazolin-4-amine

Anti-amyloid activity, Aß1-42 fibril formation IC50 = 42.6 µM, and DC50 = 22.7 µM, ß-secretase EC50 = 15 µM 

Chemical Formula: C21H16N6

Molecular Weight: 352.4

OTAVAchemicals Catalogue Number:  7070707106

CAS Registry Number:  733807-13-1

Purity:  95%

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