Protease Targeted Libraries
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Protease Targeted Libraries

Protease focused librariesProteases constitute one of the largest potential drug target enzyme families, with 647 human gene products incorporating protease sequences and mutated proteases having been identified. In addition, there are many more proteases found in viruses, bacteria, and parasites, which are also potential drug targets. The therapeutic promise of protease inhibitors has been most clearly demonstrated by angiotensin-converting enzyme (ACE) and HIV drugs. Inhibition of protease activity modulates physiological functions, either by reducing the formation of undesirable peptide mediators or by enhancing the beneficial effects of peptides by preventing their catabolism.


OTAVAchemicals offers Protease Targeted Libraries designed with Ligand-based approach. These libraries are proposed for screening in protease-associated research and drug development projects.

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available


You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Details
Human presequence protease agonist library 1050 Ligand-based read more
Matrix metalloproteinase-2 (MMP2) targeted Library 726 Ligand-based read more
Kallikrein 6 (KLK6) targeted library 648 Receptor-basedLigand-based read more
Renin Targeted Library 1001 Ligand-basedReceptor-based read more
Trypsin targeted library 51 Ligand-based -
Factor Xa targeted library 122 Ligand-based -
Tryptase targeted library 139 Ligand-based -
Cathepsin B targeted library 275 Ligand-based -
Cathepsin L targeted library 71 Ligand-based -
Cathepsin T targeted library 1550 Ligand-based -
Cathepsin K targeted library 761 Receptor-based read more
Subtilisin inhibitor library 91 Ligand-based -
HCV serine protease targeted library 1300 Ligand-based -
Matrix metalloproteinase-1 targeted library 39 Ligand-based -
Matrix metalloproteinase targeted library 16 Ligand-based -
Metalloproteinase targeted library 21 Ligand-based -
Metalloproteinase-9 targeted library 608 Ligand-based -
Caseinolytic protease ClpP targeted library 825 Receptor-based read more
Caspase 2 targeted library 480 Receptor-based read more


OTAVAchemicals Targeted Libraries Collection
Name Number
Kinases 69
Proteases 17
GPCRs 51
Ion channels 5
Disease-based libraries 74
Epigenetic targets 8
Protein-Protein Interaction 2
Peptidomimetic 2
Nuclear Receptors 12
Glycomimetic 1
RNA binding 1
SH2 binding 1
General Activities 128
Other 93



The libraries (SDF, XLS, PDF format) are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.





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