Virtual Chemical Building Blocks
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  • Adamed (Poland)
  • Cayman Chemical Company (USA)
  • Devgen NV (Belgium)
  • EMD Biosciences, Inc. (USA)
  • Santa Cruz Biotechnolgy (USA)
  • Sigma-Aldrich (USA)
  • Tocris Bioscience (UK)

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Virtual Chemical Building Blocks

OTAVAchemicals Virtual Chemical Building Blocks (about 3,900,000 compounds in total) are chemically feasible compounds that could be synthesized and delivered within 4-12 weeks (this is estimated lead time which could be changed during the synthesis). Typically, the synthesis is carried out "from scratch" according to the methodologies for chemical analogs synthesized by us previously or described in literature.

This constantly growing compound collection is a unique opportunity to order new chemical building blocks that are not available from other suppliers. 
About 500 novel building blocks were synthesized last year with average lead time ~ 8 weeks and high success rate. Interactive biweekly reports are available on your requests and you pay only after getting the ordered materials. 
We use traditional as well as cheminformatics-based principles in the design of our chemical building blocks. These compounds could be used for high-throughput and combinatorial synthesis of pharmaceutical libraries, scale-up of lead compounds for further development and it is also ideally suited for diversity-oriented syntheses as well as screening purposes. Designing unique fragment libraries is another possible application of the virtual chemicals building blocks from this collection.
Explore OTAVAchemicals Virtual Chemical Building Blocks using our On-line structure search engine – your imaginary structure could just be one click away.





  • Discovery and characterization of synthetic 4’-hydroxyflavones - New CK2 inhibitors from flavone family. Golub A.G., Bdzhola V.G., Ostrynska O.V., Kyshenia I.V., Sapelkin V.M., Prykhod’ko A.O., Kukharenko O. P., Yarmoluk S.M. Bioorg. Med. Chem. 2013, 21, 6681-6689. 
    PMID: 24011954
  • Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Golub AG, Bdzhola VG, Briukhovetska NV, Balanda AO, Kukharenko OP, Kotey IM, Ostrynska OV, Yarmoluk SM. Eur J Med Chem, 2011, 46(3):870-876. 
    PMID: 21276643
  • Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. A.G. Golub, O.Ya.Yakovenko, A.O. Prykhod'ko, S.S. Lukashov, V.G. Bdzhola, S.M. Yarmoluk. Biochimica et Biophysica Acta – 2008. – V.1784, ? 1, P. 143–149. 
    PMID: 18021749
  • Evaluation of 3-Carboxy-4(1H)-quinolones as Inhibitors of Human Protein Kinase CK2. Golub AG, Yakovenko OY, Bdzhola VG, Sapelkin VM, Zien P, Yarmoluk SM.  J Med Chem. 2006; 49(22), 6443-50. 
    PMID: 17064064

See full list of publications...