7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide

Potent multi-acting HDAC, EGFR, and HER2 inhibitor.

HDAC enzyme assay IC50 = 6.5 nM, EGFR = 3.1 nM, HER2 = 19.0 nM

OTAVAchemicals Catalogue Number:  7070707144

CAS Registry Number:  1012054-55-5

Purity:  95%+

N-Hydroxy-7-(2-naphthalenylthio)-heptanamide

HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC₅₀ = 100 nM)

OTAVAchemicals Catalogue Number: 7070707016

CAS Registry Number: 926908-04-5

Purity: 98% (HPLC)

3-pyridylmethyl N-[[4-[[2-amino-5-(2-thienyl)phenyl]carbamoyl]phenyl]methyl]carbamate

Histone deacetylase HDAC1 inhibitor IC50 = 6 nM, HCT-116 mouse xenograft model GI50 = 155 nM 

Chemical Formula: C25H22N4O3S

Molecular Weight: 458.5

OTAVAchemicals Catalogue Number:  7070707090

CAS Registry Number:  849233-98-3

Purity:  98%

4-acetamido-N-[2-amino-5-(2-thienyl)phenyl]benzamide

Histone deacetylase HDAC1/2 selective inhibitor, HDAC1 IC50 = 0.007 µM, HDAC2 IC50 = 0.049 µM,

HCT116 proliferation assay GI50 = 0.11 µM 

OTAVAchemicals Catalogue Number: 7070707091

CAS Registry Number: 849234-64-6

Purity: 97%

methyl N-[[4-[[2-amino-5-(2-thienyl)phenyl]carbamoyl]phenyl]methyl]carbamate

Histone deacetylase HDAC1 inhibitor IC50 = 6 nM, HCT-116 mouse xenograft model GI50 = 100 nM

OTAVAchemicals Catalogue Number: 7070707089

CAS Registry Number: 1013330-84-1

Purity: 98%