3-[(6,7-Dimethoxy-4-quinazolinyl)amino]-phenol

Inhibitor of IgE-mediated mast cell responses. Tau-Tubulin Kinase 1 inhibitor, phosphorylated TTBK1 KD = 0.46 µM, nonphosphorylated TTBK1 KD = 0.24 µM.

REarranged during Transfection (RET) kinase inhibitor, IC50 = 5 nM, KDR (VEGFR2) kinase inhibitor, IC50 = 66 nM

OTAVAchemicals Catalogue Number: 7015070102

CAS Registry Number: 211555-08-7

Purity: 97% (HPLC)

2-({2-[(3-fluorophenyl)amino]pyrimidin-4-yl}amino)benzoic acid

Molecular Weight: 324.3172

OTAVAchemicals Catalogue Number: 6543537

CAS Registry Number: 929007-58-9

Purity: 95% (HPLC)

3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

A potent, ATP-binding site targeting and reversible inhibitor of GSK-3, JAK3, PKCa and PKC (IC50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50 = 1.017, 2.55 and 8.055 µM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50 = 0.525, 1.294 and 0.689 µM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively)

OTAVAchemicals Catalogue Number: 7070707149

CAS Registry Number: 1260181-14-3

Purity: 97% (HPLC)

5-[(5-Nitro-2-thiazolyl)thio]-1,3,4-thiadiazol-2-amine (Halicin)

A selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 µM)

OTAVAchemicals Catalogue Number: 7070707069

CAS Registry Number: 40045-50-9

Purity: 95%+ (HPLC)

(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide

A potent antitumor agent (in vitro IC50 = 5.6 and 3.7 µM)

OTAVAchemicals Catalogue Number: 7070707057

CAS Registry Number: 857064-38-1

Purity: 95%+ (HPLC)

4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

JAK3 inhibitor, IC50 = 78 µM

OTAVAchemicals Catalogue Number: 7015070103

CAS Registry Number: 202475-60-3

Purity: 97% (HPLC)