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The OTAVA G9a Targeted Library comprises 561 carefully curated small molecules aimed at modulating the activity of histone methyltransferase G9a (EHMT2)—a master regulator of transcriptional repression through histone H3 lysine 9 (H3K9) methylation. This collection provides a powerful resource for researchers exploring epigenetics-driven mechanisms in cancer, neurodegeneration, inflammation, and stem cell reprogramming.
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The OTAVA MolGluesLike Compounds Library is a scientifically curated collection of 871 small molecules designed to enable the discovery and development of molecular glues — a groundbreaking modality in drug discovery that stabilizes or induces protein-protein interactions (PPIs).
These specialized compounds have the potential to redefine therapeutic strategies by targeting previously “undruggable” proteins, offering exciting opportunities in areas such as oncology, immunology, and neurodegenerative disease research.
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CHEMriya™ is an ultra-large combinatorial Chemical Space developed by OTAVA to transform hit expansion, hit-to-lead optimization, and compound evolution. Designed to accelerate drug discovery, CHEMriya provides access to a vast collection of chemically diverse molecules for pharmaceutical research and computational screening.
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The OTAVA Covalent Inhibitors Library is a meticulously curated collection of small-molecule covalent inhibitors, each designed to form stable, often irreversible, bonds with target proteins. These compounds feature nucleophile-sensitive functional groups that enable precise and selective inhibition, making them powerful tools in modern drug discovery.
Covalent inhibitors are widely recognized for their enhanced potency, prolonged target engagement, and unique therapeutic advantages, particularly in oncology, infectious diseases, neurodegenerative disorders, and enzyme-related conditions. By forming covalent interactions with critical amino acid residues such as cysteine, serine, lysine, and histidine, these compounds provide long-lasting inhibition that can overcome resistance mechanisms and improve drug efficacy.
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OTAVA's CELMoDs (Cereblon E3 Ligase Modulators) library represents a cutting-edge innovation in the field of targeted protein degradation. Building on the foundational breakthroughs of IMiDs (Immunomodulatory Drugs), PROTACs (Proteolysis Targeting Chimeras), and molecular glue technologies, this library focuses on compounds that harness and enhance cereblon (CRBN)-mediated degradation pathways. These compounds are meticulously designed to stabilize CRBN's closed conformation, facilitating selective and efficient degradation of disease-relevant target proteins.
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Embark on a new era of drug discovery as OTAVA’s CHEMRIYA™ Virtual Chemical Space integrates with CHEESE Search, the advanced AI-powered platform by Deep MedChem.
Unparalleled Chemical Diversity:
Access a subset of CHEMRIYA™, a next-generation virtual chemical space tailored for hit expansion, hit-to-lead, and lead optimization.
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 The COVID-19 pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target for this coronavirus is the main protease (3C-like proteinase, 3CLpro, Mpro) because of its essential role in processing the polyproteins that are translated from the viral RNA.
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 Natural Product-Like Library has been designed as a special screening library containing synthetic compounds similar to natural products.
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 Catechol O‑Methyl Transferase (COMT, HEL-S-98n) degrades catecholamines, catecholestrogens and various drugs having a catechol structure. Mutation of COMT is associated with obsessive-compulsive disorder in men, anxiety phenotypes in women, schizophrenia and other. Developing of the COMT inhibitors is a promising area of neuropsychiatric research. Also catechol‐O‐methyltransferase inhibitors are used as adjuvants to the levodopa/AADC inhibitor therapy for Parkinson's disease treatment.
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 Enhancer of zeste homolog 2 (EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit) is a histone-lysine N-methyltransferase. This enzyme plays an important role in histone methylation and, ultimately, transcriptional repression.
Mutation or over-expression of EZH2 has been linked to many forms of cancer, including bladder, uterine, breast, prostate and renal cancers. EZH2 inhibits genes responsible for suppressing of tumor development, and blocking of it activity may slow tumor growth. Therefore, EZH2 is an attractive target for anti-cancer therapy.
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The Targeted AHR Modulator Library is a curated chemical screening set designed to accelerate the discovery of novel small-molecule modulators of the aryl hydrocarbon receptor (AHR) — a ligand-dependent transcription factor with key roles in immunity, cancer, inflammation, and xenobiotic metabolism.
This unique compound library supports early-stage discovery, target validation, and therapeutic innovation by providing access to structurally diverse and computationally prioritized molecules tailored for AHR-centric research and drug development programs.
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SuFEx (Sulfur-Fluoride Exchange) Chemistry represents the next-generation approach to covalent drug discovery, chemical biology, and synthetic chemistry. Building on the principles of click chemistry, SuFEx reactions leverage the unique S(VI)–F bond, allowing precise and high-yielding chemical transformations under mild conditions.
OTAVA, in collaboration with Melius Organics, introduces a comprehensive SuFEx Handle Fragment Library, a diverse collection of aryl fluorosulfates and sulfamoyl fluorides designed to expand the druggable proteome, enhance covalent drug development, and facilitate advanced chemical synthesis.
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Tissue transglutaminase 2 (tTG2) is a multifunctional enzyme involved in extracellular matrix stabilization, cell adhesion, signal transduction, and protein crosslinking. It plays a pivotal role in various physiological processes, but its dysregulation has been implicated in multiple diseases, including celiac disease, fibrosis, cancer, and neurodegenerative disorders. Due to its involvement in disease progression, tTG2 is a prime target for drug discovery, yet the development of small-molecule inhibitors remains an underexplored frontier.
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The OTAVA USP30 Targeted Library is a cutting-edge collection of 624 meticulously curated chemical compounds designed for the identification and development of inhibitors targeting ubiquitin-specific protease 30 (USP30). By leveraging advanced computational methods and adhering to modern medicinal chemistry standards, this library offers researchers a unique toolset to explore therapeutic avenues for critical diseases.
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OTAVAchemicals Innovative Therapeutic Targets Library (2989 compounds in total) is designed to accelerate the discovery of inhibitors for key proteins, including farnesyl protein transferase (FPT), HIV-1 capsid protein p24 (GAG), exportin 1 (XPO1), and β-cardiac myosin 7 (MYH7). Developed using DrugBank and ZINC databases and incorporating machine learning for virtual screening, this library offers a curated collection of molecules for advancing drug development by enhancing screening efficiency and accuracy. 
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SARS-CoV-2 Targeted Libraries |
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 The pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global concern for public health with thousands of fatalities. Today, no specific drugs are available to treat this disease. Thus, there remains an urgent need for the development of specific antiviral therapeutics toward SARS-CoV-2.
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 RNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an enzyme that catalyzes the replication of RNA from an RNA template. RdRPs play a vital role in the growth of RNA viruses and are important targets for antiviral drug development.
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 The PDZ domains play key roles in anchoring receptor proteins in the membrane to cytoskeletal components, different intracellular signal transduction pathways and many human diseases are associated with their dysregulation.
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 Lysine-specific demethylase 4C (GASC1, KDM4C, JHDM3C, JMJD2C, TDRD14C, bA146B14.1) is a histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby plays a central role in histone modification. Abnormal functioning of this epigenetic factor is associated with different cancers, including breast cancer. Targeted inhibition of GASC1 in cancer opens new avenues for therapeutic development.
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 Cathepsin K (CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD) is a lysosomal cysteine protease involved in bone remodeling and resorption. It has a major role in osteoporosis and other bone-related pathologies, cancer, diabetes, obesity and atherosclerosis. Cathepsin K inhibitors show great potential in the treatment of such diseases.
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