Multi kinase inhibitors

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Multi kinase inhibitors


3476873

8-hydroxyquinoline-5-carboxylic acid

IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of ß-thalassemia by a-globin downregulation

Chemical Formula: C10H7NO3

Molecular Weight: 189.2

OTAVAchemicals Catalogue Number: 3476873

CAS Registry Number: 5852-78-8

Purity: 96%+ (HPLC)

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7070707024

Selective_DNA-PK_and_mTOR_inhibitor

2-(4-Morpholinyl)-4H-Pyrimido[2,1-a]isoquinolin-4-one

Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 ìM respectively). Displays little affinity for other 
commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 ìM). Induces apoptosis in vitro
 
OTAVAchemicals Catalogue Number: 7070707024

CAS Registry Number: 168425-64-7

Purity: 97%+ (HPLC)

 

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0117392020

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

potent inhibitor of sirtuin 2 (SIRT2) with IC50 = 3.5 ìM. Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 ìM

Chemical Formula: C23H13Cl2N3O2

Molecular Weight: 434.3

OTAVAchemicals Catalogue Number: 0117392020

CAS Registry Number: 304896-28-4

Purity: 98% (HPLC)

 

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7119860038

nw-daidzein

daidzein (7-Hydroxy-3-(4-hydroxyphenyl) chromen-4-one)

Potent inhibitor of monoamine oxidase (MAO) and aldehyde dehydrogenase (ALDH-2)

with IC50 = 14 μM  and 9 μM, respectively.

OTAVAchemicals Catalogue Number:   7119860038

CAS Registry Number:  486-66-8

Purity: 99%

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7015070102

Cyclin-dependent_Kinase_CDK_Inhibitor

3-[(6,7-Dimethoxy-4-quinazolinyl)amino]-phenol

Inhibitor of IgE-mediated mast cell responses. Tau-Tubulin Kinase 1 inhibitor, phosphorylated TTBK1 KD = 0.46 µM, nonphosphorylated TTBK1 KD = 0.24 µM.

REarranged during Transfection (RET) kinase inhibitor, IC50 = 5 nM, KDR (VEGFR2) kinase inhibitor, IC50 = 66 nM

OTAVAchemicals Catalogue Number: 7015070102

CAS Registry Number: 211555-08-7

Purity: 97% (HPLC)

 

 

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7070707143

Dual VEGFR-2 and tubulin inhibitor

(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(5-{2-[(pyridin-4-ylmethyl)-amino]-phenyl}-[1,3,4]oxadiazol-2-yl)-amine

 Tubulin polymerization inhibitor ITP IC50 =  1.09 µM, G2/M transition block EC50 = 0.009 µM,

VEFGR-2 enzyme IC50 = 0.21 µM, VEGFR-2 cell IC50 = 0.11 µM

OTAVAchemicals Catalogue Number:  7070707143

CAS Registry Number:  830333-53-4

Purity:  95%+

 

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1156353

Inhibitor_of_the_VEGFR-2_and_basic_fibroblast_growth_factor_FGF_kinases3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide (CP-547632)

potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 = 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor ß, and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM

OTAVAchemicals Catalogue Number: 1156353

CAS Registry Number: 252003-65-9

Purity: 95%+ (HPLC)

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1156360

PDGFR_VEGFR_and_FGFR_inhibitor

5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (NSC 702827; SU 6668; TSU 68)

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo.

OTAVAchemicals Catalogue Number: 1156360

CAS Registry Number: 252916-29-3

Purity: 95%+ (HPLC)

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1156355

Antagonist_of__VEGFR_EGFR

N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine (Vandetanib; ZD6474; Zactima)

selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. It also inhibits RET-tyrosine kinase activity, an important growth driver in certain types of thyroid cancer

OTAVAchemicals Catalogue Number: 1156355

CAS Registry Number: 443913-73-3

Purity: 95%+ (HPLC)

 

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7070707144

HDAC, EGFR, and HER2 Inhibitor

7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide

Potent multi-acting HDAC, EGFR, and HER2 inhibitor.

HDAC enzyme assay IC50 = 6.5 nM, EGFR = 3.1 nM, HER2 = 19.0 nM

OTAVAchemicals Catalogue Number:  7070707144

CAS Registry Number:  1012054-55-5

Purity:  95%+

 

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