Nuclear Receptors
     
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Nuclear Receptors

Nuclear receptor focused librariesNuclear receptors are major targets for drug discovery and have key roles in development and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. One of the most promising aspects of nuclear receptor pharmacology is that it is now possible to develop ligands with a large spectrum of full, partial or inverse agonist or antagonist activities, but also compounds, called selective nuclear receptor modulators, that activate only a subset of the functions induced by the cognate ligand or that act in a cell-type-selective manner. [1].

 

 
OTAVAchemicals offers Nuclear Receptor Targeted Libraries designed with receptor-based approach. These libraries are proposed for screening in nuclear receptor research and drug development projects.

  • the libraries contain drug-like compounds only

  • all the compounds are in stock

  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Details
RAR-related Orphan Receptor-γ Targeted Library 1326 Ligand-basedReceptor-based read more
Estrogen receptor α (ERα) agonist library 529 Ligand-based read more
Estrogen receptor α (ERα) antagonist library 398 Ligand-based read more
Estrogen receptor β (ERβ) agonist library 416 Ligand-based read more
Estrogen receptor β (ERβ) antagonist library 464 Ligand-based read more
Estrogen receptor α/β (ERα/ERβ) agonist library 556 Ligand-based read more
Estrogen receptor α/β (ERα/ERβ) antagonist library 511 Ligand-based read more
Selective estrogen receptor modulators (SERMs) targeted library 1210 Ligand-based read more
Selective androgen receptor modulators (SARMs) targeted library 1233 Ligand-based read more
Glucocorticoid receptor antagonist library 1026 Receptor-based read more
Liver X receptor beta modulator library 436 Receptor-based read more
Estrogen related receptor gamma (ERRγ) targeted library 950 Ligand-basedReceptor-based read more

OTAVAchemicals Targeted Libraries Collection
Name Number
Kinases 69
Proteases 17
GPCRs 51
Ion channels 5
Disease-based libraries 74
Epigenetic targets 8
Protein-Protein Interaction 2
Peptidomimetic 2
Nuclear Receptors 12
Glycomimetic 1
RNA binding 1
SH2 binding 1
General Activities 128
Other 93

 

 

The libraries (SDF, XLS, PDF format) are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

  1. Gronemeyer H, Gustafsson JA, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov. 2004 (11) 950-64.
 
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