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Publications

SELECTED RESEARCH ARTICLES:

  1. Galyna Volynets, Fabian Barthels, Stefan Hammerschmidt, Olena Moshynets, Sergiy Lukashov, Sergiy Starosyla, Hanna Vyshniakova, Olga S. Iungin, Volodymyr Bdzhola, Andrii Prykhod’ko, Anatolii Syniugin, Vladislav Sapelkin, Sergiy Yarmoluk, Tanja Schirmeister (2022) Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening. Journal of Antibiotics, 75(6), pp. 321–332
  2. Rybak MYu, Balanda AO, Yatsyshyna AP, Kotey IM, Starosyla SA, Bdzhola VG, Lukash LL, Yarmoluk SM, Tukalo MA, Volynets GP (2021) Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases. Scientific Reports 11:7162.
  3. Starosyla S. A., Volynets G. P., Protopopov M. V., Koleiev I. M., Bdzhola V. G., Yarmoluk S. M. (2021) Development of receptor-based protein kinase Cβ (PKCβ) pharmacophore model for the search of inhibitors with potential activity against acute respiratory distress syndrome (ARDS) Biopolym. Cell. 37(6):469-474.
  4. Galyna Volynets, Hanna Vyshniakova, Georgiana Nitulescu, George Mihai Nitulescu, Anca Ungurianu, Denisa Margina, Olena Moshynets, Volodymyr Bdzhola, Ihor Koleiev, Olga Iungin, Sergiy Tarnavskiy, Sergiy Yarmoluk (2021) Identification of novel antistaphylococcal hit compounds targeting sortase A. Molecules, 26(23), 7095
  5. Volynets Galyna, Vdovin Vasyl, Lukashov Sergiy, Borovykov Oleksiy, Borysenko Iryna, Gryshchenko Andrii, Bdzhola Volodymyr, Iatsyshyna Anna, Lukash Lyubov, Bilokin Yaroslav, Yarmoluk, Sergiy (2021) Identification of Novel Indazole-based Inhibitors of Fibroblast Growth Factor Receptor 1 (FGFR1). Current Enzyme Inhibition, Volume 17, Number 3, pp. 161-165(5)
  6. Volynets GP, Tukalo MA, Bdzhola VG, Derkach NM, Gumeniuk MI, Tarnavskiy SS, Yarmoluk SM (2020) Novel isoniazid derivative as promising antituberculosis agent. Fut Microbiol 15:869-879
  7. Protopopov MV, Vdovin VS, Starosyla SA, Borysenko IP, Prykhod'ko AO, Lukashov SS, Bilokin YV, Bdzhola VG, Yarmoluk SM (2020) Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2. Bioorg Chem 102:104062.
  8. Volynets GP, Starosyla SA, Rybak MYu, Bdzhola VG, Kovalenko OP, Vdovin VS, Yarmoluk SM, Tukalo MA (2019) Dual-targeted hit identification using pharmacophore screening. J Comput-Aided Mol Des 33:955-964.
  9. Kovalenko OP, Volynets GP, Rybak MYu, Starosyla SA, Gudzera OI, Lukashov SS, Bdzhola VG, Yarmoluk SM, Boshoff HI, Tukalo MA (2019) Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines. MedChemComm 10:2161-2169.
  10. Volynets GP, Tukalo MA, Bdzhola VG, Derkach NM, Gumeniuk MI, Tarnavskiy SS, Starosyla SA, Yarmoluk SM (2019) Benzaldehyde thiosemicarbazone derivatives against replicating and nonreplicating Mycobacterium tuberculosis. J Antibiot 72:218-224.
  11. Volynets GP, Lukashov SS, Borysenko IP, Gryshchenko AA, Starosyla SA, Bdzhola VG, Ruban TP, Iatsyshyna AP, Lukash LL, Bilokin YV, Yarmoluk SM (2019) Identification of protein kinase fibroblast growth factor receptor 1 (FGFR1) inhibitors among the derivatives of 5-(5,6-dimethoxybenzimidazol-1-yl)-3-hydroxythiophene-2-carboxylic acid. Monatshefte fur Chemie - Chemical Monthly 150:1801-1808.
  12. Kotey IM, Protopopov MV, Starosyla SA, Balanda AO, Pletnova LV, Prykhod’ko AO, Bdzhola VG, Yarmoluk SM (2019) Identifiation of 4-methoxythieno[2,3-d]pyrimidines as FGFR1 Inhibitors. Biopolym Cell 35(2):152-162.
  13. Kovalska V, Kuperman M, Losytskyy M, Vakarov S, Potocki S, Yarmoluk S, Voloshin Y, Varzatskii O, Gumienna-Kontecka E (2019) Induced CD of iron(II) clathrochelates: sensing of the structural and conformational alterations of serum albumins. Metallomics 11:338-348.
  14. Tarnavskiy SS, Protopopov MV, Borovykov OV, Pryhodko AO, Bdzhola VG, Yarmoluk SM (2019) Hit identification of FGFR1 inhibitors using receptor-based virtual screening. Biopolym Cell 35(2):143-151.
  15. Kuperman MV, Snihirova YV, Kryvorotenko DV, Losytskyy MY, Kovalska VB, Yarmoluk SM (2018) N-alkylaryl styrylcyanine dyes as fluorescent probes for nucleic acids detection. Biopolym Cell 34(5):374-386.
  16. Losytskyy MYu, Akbay N, Chernii SV, Kryvorotenko DV, Yarmoluk SM, Kovalska VB (2018) Metal-enhanced fluorescence of the trimethine cyanine dyes complexed with amyloid fibrils. J Luminescence 204:209-215.
  17. Protopopov MV, Volynets GP, Starosyla SA, Vdovin VS, Lukashov SS, Bilokin YV, Bdzhola VG, Yarmoluk SM (2018) Identification of 1,3-thiazole-5-carboxylic acid derivatives as inhibitors of protein kinase CK2. Curr Enzyme Inhib 14(2):152-159.
  18. Losytskyy M, Akbay N, Chernii S, Avci E, Chernii V, Yarmoluk S, Culha M, Kovalska V (2018) Characterization of the interaction between phthalocyanine and amyloid fibrils by surface-enhanced raman scattering (SERS). Anal Lett 51(1-2):221-228.
  19. Protopopov MV, Ostrynska OV, Starosyla SA, Vodolazhenko MA, Sirko SM, Gorobets NY, Bdzola VG, Desenko SM, Yarmoluk SM (2018) Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-4-ones as a new class of CK2 inhibitors. Mol Div doi: 10.1007/s11030-018-9836-1.
  20. Kovalska  V, Chernii S, Losytskyy M, Ostapko J, Tretyakova I, Gorski A, Chernii V, Yarmoluk S (2018) Activity of Zn and Mg phthalocyanines and porphyrazines in amyloid aggregation of insulin. J Mol Recog 31(1) doi: 10.1002/jmr.2660.
  21. Yoon JH, Mo JS, Kim MY, Ann EJ, Ahn JS, Jo EH, Lee HJ, Lee YC, Seol W, Yarmoluk SM, Gasser T, Kahle PJ, Liu GH, Belmonte JCI, Park HS (2017) LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death. Biochim Biophys Acta Mol Cell Res 1864(12):2356-2368.
  22. Kuperman MV, Losytskyy MYu, Bykov AYu, Yarmoluk SM, Zhizhin KYu, Kuznetsov NT, Varzatskii OA, Gumienna-Kontecka E, Kovalska VB (2017) Effective binding of perhalogenated closo-borates to serum albumins revealed by spectroscopic and ITC studies. J Mol Struct 1141:75-80.
  23. Kovalska V, Chernii S, Cherepanov V, Losytskyy M, Chernii V, Varzatskii O, Naumovets A, Yarmoluk S (2017) The impact of binding of macrocyclic metal complexes on amyloid fibrillization of insulin and lysozyme. J Mol Recog 30(8) doi: 10.1002/jmr.2622.
  24. Tatikolov AS, Akimkin TM, Panova IG, Yarmoluk SM (2017) Spectral-fluorescent study of the interaction of the polymethine dye probe Cyan 2 with chondroitin-4-sulfate. Spectrochim Acta A Mol Biomol Spectroscopy 177:93-96.
  25. Niefind K, Bischoff N, Golub AG, Bdzhola VG, Balanda AO, Prykhod'ko AO, Yarmoluk SM (2017) Structural hypervariability of the two human protein kinase CK2 catalytic subunit paralogs revealed by complex structures with a flavonol- and a thieno[2,3-d]pyrimidine-based inhibitor. Pharmaceuticals (Basel) 10(1):pii:E9. 
  26. Zinchenko AN, Muzychka LV, Smolii OB, Bdzhola VG, Protopopov MV, Yarmoluk SM (2017) Synthesis and biological evaluation of novel amino-substituted derivatives of pyrido[2,3-d]pyrimidine as inhibitors of protein kinase CK2. Biopolym Cell 33(5):367-378.
  27. Protopopov MV, Starosyla SA, Borovykov OV, Sapelkin VN, Bilokin YV, Bdzhola VG, Yarmoluk SM (2017) Hit identification of CK2 inhibitors by methods of virtual screening. Biopolym Cell 33(4):291-301. 
  28. Kuperman M, Chernii S, Varzatskii O, Zhdanov A, Bykov A, Zhizhin K, Yarmoluk S, Kovalska V (2017) The discovery of the effect of closo-borate on amyloid fibril formation. ChemistrySelect 2(34):10965-10970.
  29. Syniugin AR, Ostrynska OV, Chekanov MO, Volynets GP, Starosyla SA, Bdzhola VG, Yarmoluk SM (2016) Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2. J Enzyme Inhib Med Chem doi: 10.1080/14756366.2016.1222584.
  30. Volynets GP, Gorbatiuk OB, Kukharenko OP, Usenko MO, Yarmoluk SM (2016) Production of recombinant human apoptosis signal-regulating kinase 1 (ASK1) in Escherichia coli. Prot Expr Purif 126:89-92.
  31. Syniugin AR, Chekanov MO, Savitskiy PV, Pashenko AE, Zhuk TS, Yarmoluk SM, Fokin AA (2016) New method for the synthesis of pyrrolo[2,3-b]dihydroquinolines. Tetrahedron Lett 57(2):213-215.
  32. Kovalska V, Chernii S, Losytskyy M, Dovbii Y, Tretyakova I, Czerwieniec R, Chernii V, Yarmoluk S, Volkov S (2016) b-ketoenole dyes: synthesis and study as fluorescent sensors for protein amyloid aggregates. Dyes and Pigments 132:274-281.
  33. Gudzera OI, Golub AG, Bdzhola VG, Volynets GP, Kovalenko OP, Boyarshin KS, Yaremchuk AD, Protopopov MV, Yarmoluk SM, Tukalo MA (2016) Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one. J Enzyme Inhib Med Chem doi: 10.1080/14756366.2016.1190712.
  34. Gryshchenko AA, Tarnavskiy SS, Levchenko KV, Bdzhola VG, Volynets GP, Golub AG, Ruban TP, Vygranenko KV, Lukash LL, Yarmoluk SM (2016) Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1. Bioorg Med Chem 24(9):2053-2059.
  35. Gudzera OI, Golub AG, Bdzhola VG, Volynets GP, Lukashov SS, Kovalenko OP, Kriklivyi IA, Yaremchuk AD, Starosyla SA, Yarmoluk SM, Tukalo MA (2016) Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase. Bioorg Med Chem 24(5):1023-1031.
  36. Ostrynska OV, Balanda AO, Bdzhola VG, Golub AG, Kotey IM, Kukharenko OP, Gryshchenko AA, Briukhovetska NV, Yarmoluk SM (2016) Design and synthesis of novel protein kinase CK2 inhibitors on the base of 4-aminothieno[2,3-d]pyrimidines. Eur J Med Chem 115:148-160.
  37. Losytskyy MYu, Kovalska VB, Varzatskii OA, Kuperman MV, Potocki S, Gumienna-Kontecka E, Zhdanov AP, Yarmoluk SM, Voloshin YZ, Zhizhin KYu, Kuznetsov NT, Elskaya AV (2016) An interaction of the functionalized closo-borates with albumins: The protein fluorescence quenching and calorimetry study. J Luminesc 169:51-60.
  38. Starosyla SA, Volynets GP, Lukashov SS, Gorbatiuk OB, Golub AG, Bdzhola VG, Yarmoluk SM (2015) Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorg Med Chem 23(10):2489-2497.
  39. Guerra B, Bischoff N, Bdzhola VG, Yarmoluk SM, Issinger OG, Golub AG, Niefind K (2015) A note of caution on the role of halogen bonds for protein kinase/inhibitor recognition suggested by high- and low-salt CK2α complex structures. ACS Chem Biol 10(7):1654-1660.
  40. Gryshchenko AA, Bdzhola VG, Balanda AO, Briukhovetska NV, Kotey IM, Golub AG, Ruban TP, Lukash LL, Yarmoluk SM (2015) Design, synthesis and biological evaluation of N-phenylthieno[2,3-d]pyrimidin-4-amines as inhibitors of FGFR1. Bioorg Med Chem 23(9):2287-2293.
  41. Gryshchenko AA, Levchenko KV, Bdzhola VG, Ruban TP, Lukash LL, Yarmoluk SM (2015) Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors. J Enzyme Inhib Med Chem 30(1):126-132.
  42. Starosyla SA, Volynets GP, Bdzhola VG, Golub AG, Yarmoluk SM (2014) Pharmacophore approaches in protein kinase inhibitors design. World J Pharmacol 3(4):162-173.
  43. Starosyla SA, Volynets GP, Bdzhola VG, Golub AG, Protopopov MV, Yarmoluk SM (2014) ASK1 pharmacophore model derived from diverse classes of inhibitors. Bioorg Med Chem Lett 24(18):4418-4423.
  44. Vukomanovic D, Rahman MN, Bilokin Y, Golub AG, Brien JF, Szarek WA, Jia Z, Nakatsu K (2014) In vitro Activation of heme oxygenase-2 by menadione and its analogs. Med Gas Res 4(1):4.
  45. Chekanov MO, Ostrynska OV, Synyugin AR, Bdzhola VG, Yarmoluk SM (2013) Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors. J Enzyme Inhib Med Chem 29(3):338-343.
  46. Chekanov MO, Ostrynska OV, Tarnavskyi SS, Synyugin AR, Briukhovetska NV, Bdzhola VG, Pashenko AE, Fokin AA, Yarmoluk SM (2013) Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors. J Enzyme Inhib Med Chem. 29(5):639-646.
  47. Volynets G, Bdzhola V, Golub A, Synyugin A, Chekanov M, Kukharenko O, Yarmoluk S (2013) Rational Design of Apoptosis Signal-Regulating Kinase 1 Inhibitors: Discovering Novel Structural Scaffold. Eur J Med Chem 61:104-115.
  48. Golub AG, Bdzhola VG, Ostrynska OV, Kyshenia IV, Sapelkin VM, Prykhod’ko AO, Kukharenko OP, Yarmoluk SM (2013) Discovery and characterization of synthetic 4-hydroxyflavones - New CK2 inhibitors from flavone family. Bioorg Med Chem 21:6681-6689.
  49. Hunnigan K, Kulkarni SS, Bdzhola VG, Golub AG, Yarmoluk SM, Talele TT (2013) Identification of novel PARP-1 inhibitors by structure-based virtual screening. Bioorg Med Chem Lett 23:5790-5794.
  50. Golub AG, Gurukumar KR, Basu A, Bdzhola VG, Bilokin Y, Yarmoluk SM, Lee J-C, Talele TT, Nichols DB, Kaushik-Basu N (2012) Discovery of New Scaffolds for Rational Design of HCV NS5B Polymerase Inhibitors. Eur J Med Chem 58:258-264.
  51. Marti? S, Tackenburg S, Bilokin Y, Golub A, Bdzhola V, Yarmoluk S, Kraatz HB (2012) Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors. Anal Biochem 421(2):617-621.
  52. Golub AG, Bdzhola VG, Kyshenia YV, Sapelkin VM, Prykhod'ko AO, Kukharenko OP, Ostrynska OV, Yarmoluk SM (2011) Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2. Mol Cell Biochem 356(1-2):107-115.
  53. Volynets GP, Chekanov MO, Synyugin AR, Golub AG, Kukharenko OP, Bdzhola VG, Yarmoluk SM (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). Med Chem 54(8):2680-2686.
  54. Golub AG, Bdzhola VG, Briukhovetska NV, Balanda AO, Kukharenko OP, Kotey IM, Ostrynska OV, Yarmoluk SM (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem 46(3):870-876.
  55. Kramerov AA, Golub AG, Bdzhola VG, Yarmoluk SM, Ahmed K, Bretner M, Ljubimov AV (2011) Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton. Mol Cell Biochem 349(1-2):125-137.
  56. Volynets GP, Bdzhola VG, Kukharenko OP, Yarmoluk SM (2010) Identification of ASK1 small-molecule inhibitors. Ukr Biochim J 82(5): 41-50.
  57. Volynets GP, Bdzhola VG, Yarmoluk SM (2010) Methods of structural bioinformatics. Biotechnology 3(4):9-19.
  58. Grischenko AA, Bdzhola VG, Kukharenko OP, Yarmoluk SM (2009) Search for FGFR1 inhibitors among chromone derivatives. Ukrainica Bioorganica Acta 7(2):64-68.
  59. Volynets GP, Bdzhola VG, Kukharenko OP, Sovetova OV, Yarmoluk SM (2009) Protein kinase ASK1 as potential therapeutic target. Biopolymers and Cell 25(3):169-180.
  60. Golub AG, Yakovenko OYa, Prykhod'ko AO, Lukashov SS, Bdzhola VG, Yarmoluk SM (2008) Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochimica et Biophysica Acta 1784(1): 143-149.
  61. Kotey IM, Balanda AO, Bdzhola VG, Lukashov SS, Kukharenko OP, Kharchenko VM, Yarmoluk SM (2008) Synthesis and biologic evaluation of thienopyrimidinones inhibition activity against protein kinase CK2. Ukrainica Bioorganica Acta 6(2):3-9.
  62. Shablykin OV, Kucharenko OP, Iakovenko IN, Yarmoluk SM, Brovarets VS (2008) Search for specific protein kinase CK2 inhibitors and vasoactive compounds among 5-amino-1,3-oxazoles derivatives. Ukrainica Bioorganica Acta 6(1):28-36.
  63. Volynets GP, Golub AG, Bdzhola VG, Yarmoluk SM (2007) The role of protein kinase CK2 in the regulation of oncogenesis, apoptosis and cellular stress response. Ukrainica Bioorganica Acta 5(2):25-32.
  64. Yakovenko O, ?liferenko A, Bdzhola V, Palyulin V, Zefirov N (2008) Kirchhoff atomic charges fitted to multipole moments: Implementation for a virtual screening system. Journal of Computational Chemistry 29:1332-1343.
  65. Yakovenko OYa, Oliferenko AA, Golub AG, Bdzhola VG, Yarmoluk SM (2007) The new method of distribution integrals evaluations for high throughput virtual screening. Ukrainica Bioorganica Acta 5(1):52-62.
  66. Yakovenko OYa, Golub AG, Bdzhola VG, Yarmoluk SM (2006) Application of distribution function of rotation and translation degrees of freedom for CK2 inhibitors Ki estimation. Ukrainica Bioorganica Acta 4(2):47-55.
  67. Golub AG, Yakovenko OY, Bdzhola VG, Sapelkin VM, Zien P, Yarmoluk SM (2006) Evaluation of 3-Carboxy-4(1H)-quinolones as Inhibitors of Human Protein Kinase CK2. J Med Chem 49(22):6443-6450.
  68. Prykhod’ko AO, Yakovenko OYa, Golub AG, Bdzhola AG, Yarmoluk SM (2005) Evaluation of 4H-4-chromenone derivatives as inhibitors of protein kinase CK2. Biopolymers and cell 21(3):287-292.
  69. Sapelkin VM, Golub AG, Yakovenko OYa, Bdzhola VG, Yarmoluk SM (2005) Search for protein kinase CK2 inhibitors among 3-carboxy-4-aminoquinoline derivatives. Ukrainica Bioorganica Acta 1(1):28-32.
  70. Sapelkin VM, Golub AG, Yakovenko OYa, Bdzhola VG, Yarmoluk SM (2004) Search for casein kinase 2 inhibitors among 4 aminoquinazoline derivatives. Ukrainica Bioorganica Acta 1(1-2):74-79.
  71. Prykhod'ko AO, Dubinina GG, Golovach SM, Yarmoluk SM (2004) Inhibitors of protein kinase CK2. Ukrainica Bioorganica Acta 1(1-2):39-48.
  72. Chekanov MO, Synyugin AR, Lukashov SS, Yarmoluk SM. Synthesis of (1,1-dioxido-3-oxoisothiazolidin-2-yl)-benzenesulfonamides. Ukrainica Bioorganica Acta 6(1):55-60.
  73. Shaitanov PV, Lukashov SS, Turov OV, Yarmoluk SM (2007) Synthesis and structural study of N-substituted-1,7-dithia-4-azaspiro[4.4]nonan-3-one 7,7-dioxides. Ukrainica Bioorganica Acta 5(2):56-61.
  74. Shaitanov PV, Bezugly YuV, Sapelkin VM, Yarmoluk SM (2006) Synthesis of 4-substituted 1-arylhexahydrothieno[3,4-b]pyrazin-2(1H)-one 6,6-dioxides. Ukrainica Bioorganica Acta 4(2):40-46.
  75. Shaitanov PV, Bezugly YuV, Charchenko VM, Lukashov SM, Yarmoluk SM (2005) Synthesis and structural characteristics of 4-(2-phenylethyl)-1,7-dithia-4-azaspiro[4.4]nonan-3-one 7,7-dioxide. Ukrainica Bioorganica Acta 3(2):39-42.
  76. Prykhodko A O, Kobzev SP, Yarmoluk SM (2005) Synthesis of 7-(3-dialkylamino-2-hydroxypropoxy)-3-aryloxychromones. Ukrainica Bioorganica Acta 1(1):33-39.
  77. Prykhod’ko AO, Dubinina GG, Khilya VP, Yarmoluk SM (2004) Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluorometthyl-4H-4-chromenone derivatives against 60 human cancer cell lines. Biopolymers and cell 20(1-2):159-163.
  78. Dubinina GG, Golovach SM, Tarnavsky SS, Yarmoluk SM (2003) Interaction of 7-R-3-R1-7,8-dihydro-2H,6H-pyrrolo[3',4':4,5][1,3]thiazolo[3,2-b][1,2,4]triazine-2,6,8-triones with N-nucleophiles. Ukr Khim Zh 69(4):35-39.
  79. Lesyk RB, Zimenkovsky BS, Yarmoluk SM, Subtel’na IYu (2003) Synthesis of potential biologically active substances on the base of 5-carboxymethylidene-2,4-thiazolidinedione. Pharmaceutical journal 1:51-56.
  80. Tarnavsky SS, Dubinina GG, Golovach SM, Yarmoluk SM (2003) The relationship of antitumor activity with the structure of 3-chloro-4-(3-hydroxyanilino)-2,5-dihydropyrrole-2,5-diones. Biopolymers and Cell 19(6):548-552.
  81. Tarnavsky SS, Dubinina GG, Golovach SM, Yarmoluk SM. The search of antitumor activity among derivatives of the 2,5-dihydropyrrole-2,5-dione. Biopolymers and Cell 19(3):287-291.
  82. Sapelkin VM, Iakovenko IE, Lukashov SS, Dubinina GG, Yarmoluk SM (2003) Antitumor activity of the 6-substituted derivatives of the 4-alkylaminoquinazolines. Biopolymers and Cell 19(5):467-472.
  83. Arkhipov VV, Prykhod'ko AO, Golub AG, Khilya VP, Yarmoluk SM ((2003) Inhibitors of cyclin-dependent kinases. I. Synthesis of combinatorial libraries of 8-aminomethyl derivatives of 3-aryloxy-7-hydroxychromones and study of their antitumor activity. Biopolymers and Cell 19(2):196-201.
  84. Dubinina GG, Tarnavsky SS, Golovach SM, Yarmoluk SM (2002) Interaction of 3,4-dichloromaleimides with N- and S-nucleophiles. Ukr Khim Zh 68(8):47-51.
  85. Dubinina GG, Volovenko YuM, Yarmoluk SM, Shishkina SV, Shishkin OV (2001) Reaction of N-substituted 3,4-dichloromaleimides with a-mercaptoazaheterocycles. Heterocycles 11:2189-2198.
  86. Alekseeva IV, Palchikovska LI, Shalamay AS, Tarnavsky SS, Nosach LN, Dyachenko NS (1997) The N4-aminoacid derivatives of 6-azacytidine: Syntheses and biological activity. Biopolymers and Cell 13(4):285-290.

 

PATENTS:

  1. Pat. 117279, 26.06.2017. Novel small-molecular organic compounds with antituberculosis activity based on isonicotinic acid hydrazide. Volynets GP, Tukalo MA, Bdzhola VG, Tarnavskiy SS, Starosyla SA, Gudzera OY, Yarmoluk SM.
  2. Pat. 116134, 10.05.2017. Novel small-molecular organic compounds with antituberculosis activity based on benzaldehyde thiosemicarbazone. Volynets GP, Tukalo MA, Bdzhola VG, Starosyla SA, Tarnavskiy SS, Gudzera OY, Kriklivyi IA, Yarmoluk SM.
  3. Pat. 86041, 10.12.2013. Low-molecular organic ATP-competitive inhibitors of serine/threonine kinase CK2 based on 4-amino-thieno-[2,3-d]pyrimidine heterocycle. Ostrynska OV, Balanda AO, Bdzhola VG, Kotey IM, Kukharenko OP, Yarmoluk SM.
  4. Pat. WO2011/065980 (A2), 03.06.2011. Dyes for Analysis of Protein Aggregation. Patton WF, Yarmoluk SM, Pande P, Kovalska V, Dai L, Volkova K, Coleman J, Losytskyy M, Ludlam A, Balanda A, Shen D.
  5. Patent Application US2008091015 A1, 17.04.2008; WO 2008/027821 A1, 06.03.2008. Use of squaraine dyes to visualize protein during separations. Berkelman TR, Yarmoluk SM, Kovalska VB, Losytskyy MYu, Volkova KD.
  6. Pat. US2006207881, 21.09.2006. Detection of polyamino acids using trimethincyanine dyes. Kovalska VB, Kryvorotenko DV, Losytskyy MYu, Nording P, Rueck A, Schoenenberger B, Yarmoluk SM, Wahl F.
  7. Pat. 2004031889, 15.02.2005, Bull. â„–2, Compound 5-[(4-chlorophenyl)methylidene]-2-(4-oxyanilino)-4,5-dihydrothiazol-4-one, which possess anticancer activity. Lesyk RB, Zimenkovsky BS, Yarmoluk SM, Bdzhola VH, Vovk OI. 
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