Protein Kinase focused libraries
     
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Protein Kinase Targeted Libraries

Kinase focused librariesProtein kinases constitute a large family of proteins that is now firmly established as a major class of drug targets for the pharmaceutical industry. With so many inhibitors reported to be in clinical development and many more in preclinical development, kinase inhibitors now make up a significant fraction of most major pharmaceutical companies' pipelines, as well as an area of focus for many biotechnology companies. The increased interest in this class of targets reflects both advances in identifying selective protein kinase inhibitors and a growing perception that these drugs offer a novel, well-tolerated oral therapy in some of the most untreatable cancers.

 

 
OTAVAchemicals offers 69 Protein Kinase Targeted Libraries designed with Receptor-based or Ligand-based approach. These libraries are proposed for screening in kinasel-associated research and drug development projects.

 

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Details
1-Phosphatidylinositol-4-phosphate 5-kinase (PIPK) inhibitor library 14 Ligand-based -
Abl kinase inhibitor library 76 Ligand-based -
Acetate kinase inhibitor library 129 Ligand-based -
ADP-thymidine kinase inhibitor library 922 Ligand-based -
Aurora A kinase inhibitor library 364 Ligand-based -
Aurora B kinase inhibitor library 249 Ligand-based -
Aurora C kinase inhibitor library 1162 Ligand-based -
Beta-adrenergic receptor kinase (BARK) inhibitor library 1268 Ligand-based -
Check point kinase (CHK) inhibitor library 593 Ligand-based -
Cyclin-dependent kinase 1 (CDK1) inhibitor library 83 Ligand-based -
Cyclin-dependent kinase 2 (CDK2) inhibitor library 466 Ligand-based -
Cyclin-dependent kinase 4 (CDK4) inhibitor library 798 Ligand-based -
Cyclin-dependent kinase 5 (CDK5) inhibitor library 893 Ligand-based -
EphB2 kinase inhibitor library 329 Ligand-based -
Epidermal growth factor receptor (EGFR) kinase inhibitor library 318 Ligand-based -
Glycogen synthase kinase-3 beta (GSK3B) inhibitor library 521 Ligand-based -
G-protein-coupled receptor kinase (GRK) inhibitor library 1268 Ligand-based -
Guanidinoacetate kinase inhibitor library 254 Ligand-based -
I kappa B kinase 2 (IKK2) inhibitor library 347 Ligand-based -
Inositol-trisphosphate 3-kinase (IP3K) inhibitor library 78 Ligand-based -
Lombricine kinase inhibitor library 163 Ligand-based -
Mitogen-activated protein kinase 1 (MAPK1 ERK2) inhibitor library - Ligand-based -
Mitogen-activated protein kinase 1 (MAPK1 ERK2) inhibitor library 197 Receptor-based read more
Mitogen-activated protein kinase 9 (MAPK9 JNK2) inhibitor library - Receptor-based -
MAP kinase (MAPK) inhibitor library 102 Ligand-based -
N-acylmannosamine kinase inhibitor library 935 Ligand-based -
NADH kinase inhibitor library 871 Ligand-based -
Opheline kinase inhibitor library 875 Ligand-based -
Phosphatidylinositol 3-kinase C2 beta (PI3K-C2 beta) inhibitor library 1183 Ligand-based -
Phosphatidylinositol 3-kinase C2 gamma (PI3K-C2 gamma) inhibitor library 252 Ligand-based -
Phosphoenolpyruvate carboxykinase (PEPCK) inhibitor library 26 Ligand-based -
Platelet derived growth factor receptor (PDGFR) kinase inhibitor library 1972 Ligand-based -
Protein kinase CK1 inhibitor library 1387 Ligand-based -
Protein kinase B (PKB) inhibitor library 1070 Ligand-based -
Protein kinase C eta (PKC) inhibitor library 16 Ligand-based -
Serine-threonine kinase inhibitor library 213 Ligand-based -
Proto-oncogene tyrosine protein kinase Fyn inhibitor library 481 Ligand-based -
Proto-oncogene tyrosine protein kinase Kit inhibitor library 214 Ligand-based -
Pyridoxal kinase inhibitor library 5 Ligand-based -
Raf kinase B inhibitor library 38 Ligand-based -
Raf kinase inhibitor library 74 Ligand-based -
Rho-associated kinase inhibitor library 344 Ligand-based -
Ribosomal protein S6 kinase (S6K) inhibitor library 10 Ligand-based -
Shikimate kinase inhibitor library 453 Ligand-based -
Smooth muscle myosin light chain kinase (MLCK) inhibitor library 627 Ligand-based -
Sphinganine kinase inhibitor library 244 Ligand-based -
Sphingosine kinase inhibitor library 1119 Ligand-based -
Src kinase inhibitor library 200 Ligand-based -
Taurocyamine kinase inhibitor library 875 Ligand-based -
Thymidine kinase inhibitor library 922 Ligand-based -
Tyrosine kinase inhibitor library 1147 Ligand-based -
Urokinase inhibitor library 21 Ligand-based -
P21-activated kinase 1 (PAK1) inhibitor library 606 Receptor-based read more
Serine/threonine kinase CHK1 inhibitor library 681 Receptor-based read more
Proto-oncogene tyrosine kinase ABL1 inhibitor library 771 Receptor-based read more
Death-associated kinase 2 (DAPK2) inhibitor library 591 Receptor-based read more
p38 MAP kinase alpha targeted library 592 Receptor-based read more
Vascular endothelial growth factor receptor 2 (VEGFR2) kinase inhibitor library 648 Receptor-based read more
Aurora B kinase inhibitor library 508 Receptor-based read more
Janus kinase 2 (Jak2) inhibitor library 625 Receptor-based read more
Phosphatidylinositol 3-kinase (PI3K) inhibitor library 364 Receptor-based read more
3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor library 496 Receptor-based read more
Cyclin-dependent kinase 2 (CDK2) inhibitor library 670 Receptor-based read more
Glycogen synthase kinase 3 (GSK3) inhibitor library 479 Receptor-based read more
Fibroblast growth factor receptor 1 kinase (FGFR1K) inhibitor library 485 Receptor-based read more
cAMP dependent protein kinase (PKA) inhibitor library 408 Receptor-based read more
C-Jun N-terminal kinase 2 (Jn2) inhibitor library 1774 Receptor-based -
Death-associated protein kinase 1 (DAPK1) inhibitor library 1962 Receptor-based -
Death-associated protein kinase 3 (DAPK3) inhibitor library 1814 Receptor-based -

 

OTAVAchemicals Targeted Libraries Collection
Name Number
Kinases 69
Proteases 17
GPCRs 51
Ion channels 5
Disease-based libraries 74
Epigenetic targets 8
Protein-Protein Interaction 2
Peptidomimetic 2
Nuclear Receptors 12
Glycomimetic 1
RNA binding 1
SH2 binding 1
General Activities 128
Other 93

 

 

The libraries (SDF, XLS, PDF format) are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

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