Dual VEGFR-2 and tubulin inhibitor
OTAVAchemicals Catalogue Number: 7070707143
CAS Registry Number: 830333-53-4
Ref.: Chekler et al. Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy. ACS Med. Chem. Lett. (2010), 1, 488-492
Abstract: In an effort to develop potent, orally bioavailable compounds for the treatment of neoplastic diseases, we developed a class of dual VEGFR-2 kinase and tubulin inhibitors. Targeting the VEGFR receptor kinase and tubulin structure allows for inhibition of both tumor cells and tumor vasculature. Previously, a combination of two compounds, a VEGF receptor tyrosine kinase inhibitor and tubulin agent, was demonstrated to produce an enhanced antitumor response in animal studies. We have reaffirmed their results, with the added benefit that both activities are found in one compound.