7070707106

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7070707106

CID 9998128

N-(1H-indazol-5-yl)-2-(6-methyl-2-pyridyl)quinazolin-4-amine

Anti-amyloid activity, Aß1-42 fibril formation IC50 = 42.6 µM, and DC50 = 22.7 µM, ß-secretase EC50 = 15 µM 

Chemical Formula: C21H16N6

Molecular Weight: 352.4

OTAVAchemicals Catalogue Number:  7070707106

CAS Registry Number:  733807-13-1

Purity:  95%

Ref.: ACS Chem. Neurosci. 2018, 9,11, 2588–2598

Abstract:  In vitro experiments have shown that CID 9998128 inhibits the Aß42 amyloid fibrillization and is capable to clear Aß42 fibrils. Moreover, compound dose-dependently decreases ß-site amyloid precursor protein cleaving enzyme (BACE-1) activity with EC50 value in micromolar range.

DOI: 10.1021/acschemneuro.8b00091

 


Price info:
1 MG 20 EUR
5 MG 50 EUR
10 MG 70 EUR
300uL of 10mM solution

35 EUR

 

 

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