K-604 is a selective ACAT-1 inhibitor
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K-604 is a selective ACAT-1 inhibitor


A potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 µM



OTAVAchemicals Catalogue Number: 7070707145
CAS Registry Number: 561023-90-3
Purity: 97% (HPLC)


Ref.: Discovery of Clinical Candidate 2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.Kimiyuki Shibuya, Katsumi Kawamine, Chiyoka Ozaki, Tadaaki Ohgiya, Toshiyuki Edano, Yasunobu Yoshinaka, and Yoshihiko Tsunenari.J. Med. Chem. 2018, 61, 23, 10635-10650

Abstract: 2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)- ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)- pyridin-3-yl)acetamide hydrochloride (K-604, ) has been identified as an aqueous-soluble potent inhibitor of human acyl-coenzyme A:cholesterol O-acyltransferase (ACAT, also known as SOAT)-1 that exhibits 229-fold selectivity for human ACAT-1 over human ACAT-2.


Price info:
1 MG 79 EUR
5 MG 129 EUR
10 MG 199 EUR
300uL of 10mM solution 104 EUR