Our company, OTAVA Ltd., is offering the following chemical optimization service - synthesis of target-specific sets of novel Barbadin analogs for your biological tests. These novel compounds will be selected from a set of 1,000 unique virtual Barbadin analogs using our company’s proprietary molecular modeling platform.

These target-specific sets of novel Barbadin analogs will be synthesized exclusively upon your request.

Please note that there is no special service contract agreement and all IP will be held by your company.

See also: ß-Arrestin/ß2-Adaptin Interaction Targeted Library from OTAVA

This is referred to a paper from Nature Communications* which showed that authors, using a combination of virtual screening and cell-based assays, identified a small molecule Barbadin that selectively inhibits the interaction between ß-arrestin and the ß2-adaptin subunit of the clathrin adaptor protein AP2 without interfering with the formation of receptor/ß-arrestin complexes. ​​​​​​

Barbadin compound used in the published research was acquired from our company:

Barbadin
OTV# 0129720278

* A new inhibitor of the beta-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling, Nature Communications 8, Article number: 15054 (2017) (DOI: 10.1038/ncomms15054).

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