hPreP Agonist Library
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hPreP Agonist Library

Human Presequence Protease Activators Library A neurotoxic peptide β-amyloid (Aβ) is linked to the beginning of Alzheimer’s disease (AD). The accumulation of amyloid-beta inside mitochondria boosts production of free radical and activation of the apoptotic pathway. Human Presequence Protease (hPreP, PITRM1) is a mitochondrial ATP-independent metalloprotease. It degrades toxic peptides, including mitochondrial presequences and β-amyloid. This enzyme is an attractive target for Alzheimer’s disease drug design because enhancement of it's activity increases the level of Aβ proteolysis.

OTAVAchemicals offers a Human Presequence Protease Agonist Library (1050 compounds in total). It has been carefully designed with two approaches as a special screening library containing compounds with predicted hPreP activating activity. One part of compounds was selected by pharmacophore screening of our Drug-like Green Collection against five-point pharmacophore model offered by Vangavaragu at all. Another part was selected with Bayesian models based on fingerprints and molecular descriptors using as a template agonists of PITRM1 developed by the same authors. Top-scored ligands were picked from both screening, 30% among them overlapped. Physicochemical properties of compounds in the library are related to BBB penetration.

This library comprises molecules with increased potential for CNS bioavailability and provides an excellent basis for Alzheimer’s disease drug discovery projects.


All compounds are in stock, cherry-picking is available.

The Human Presequence Protease Agonist Library (DB, SD, XLS, PDF format) as well as the price-list is available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain this library or if you need more information.





  • Jhansi Rani Vangavaragu, Koteswara Rao Valasani, Xueqi Gan, Shirley ShiDu Yan. Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry. Vol. 76, 2014, pp. 506 -€“ 516.

The summary of the Human Presequence Protease Agonist Library characteristics:

Molecular Weight Number of Rotatable Bonds Calculated logP Calculated logS PSA Fraction of Sp3-Hybridized Carbons Number of Hydrogen Bond Donors Number of Hydrogen Bond Acceptors Number of Rings Number of Aromatic Rings

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