N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

OTAVAchemicals Catalogue Number: 7070707131
CAS Registry Number: 1226056-71-8
Purity: 95%+ (HPLC)

Ref.:  Ding et al. A chemical platform for improved induction of human iPSCs. Nature Methods (2009), 6, 805-809

Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSC s) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.