6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide ( EX-527 ) (racemic)
OTAVAchemicals Catalogue Number: 7020402314
CAS Registry Number: 49843-98-3
Purity: 97%+ (HPLC)
Ref. 1: Napper et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. Journal of Medicinal Chemistry (2005), 48, 8045-8054
The most potent compounds described in this paper inhibit SIRT1 with IC50 values of 60 -100 nM, representing a 500-fold improvement over previously reported SIRT inhibitors.
Ref. 2: Nayagam et al. SIRT1 Modulating Compounds From High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents. Journal of Biomolecular Screening (2006), 11, 959-967