Janus kinase 3 inhibitor
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Janus kinase 3 inhibitor

4-[(6,7-Dimethoxy-4-quinazolinyl)amino]-phenol (4-(4'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline; JANEX-1; WHI-P131 )

OTAVAchemicals Catalogue Number: 7015070103
CAS Registry Number: 202475-60-3
Purity: 95%+ (HPLC)

Ref.: D'Cruz et al. Targeting mast cells in endometriosis with Janus kinase 3 inhibitor, JANEX-1. American Journal of Reproductive Immunology (2007), 58, 75-97

Abstract: JANEX-1/WHI-P131 is a rationally designed novel JAK3 inhibitor with potent anti-inflammatory activity in several cellular and in vivo animal models of inflammation, including mouse models of peritonitis, colitis, cellulitis, sunburn, and airway inflammation with favorable toxicity and pharmacokinetic profile.