Hypoxia Inducible Factor-1α Inhibitor
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Hypoxia Inducible Factor-1α Inhibitor

4-Hydroxy-3-[[2-(4-tricyclo[,7]dec-1-ylphenoxy)acetyl]amino]-benzoic acid methyl ester

OTAVAchemicals Catalogue Number: 7070707015
CAS Registry Number: 934593-90-5
Purity: 97%+ (HPLC)

Ref.: Lee et al. (Aryloxyacetylamino)benzoic Acid Analogues: A New Class of Hypoxia-Inducible Factor-1 Inhibitors. Journal of Medicinal Chemistry (2007), 50, 1675-1684

Abstract: Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.