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2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid
KD for eIF4E binding is estimated of 25 µM
OTAVAchemicals Catalogue Number: 7070707011
CAS Registry Number: 315706-13-9
Purity: 98% (HPLC)
Ref.: Cell 2007, 128, 2, 257 – 267 Virology 2013, 444,171 – 180
Abstract: 4EGI-1 binds eIF4E, disrupts association of translation initiation factors into eIF4E/eIF4G complex and inhibits cap-dependent translation but not initiation factor independent translation. 4EGI-1 inhibits translation driven by poliovirus IRES, vesicular stomatitis virus and Sindbis virus despite cleavage of eIF4G by picornavirus proteases, suggesting that this molecule may affect other steps in protein synthesis unrelated to cap recognition by eIF4E.
DOI: 10.1016/j.cell.2006.11.046 10.1016/j.virol.2013.06.008
Price info:
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1 MG |
35 EUR |
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5 MG |
80 EUR |
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10 MG |
120 EUR |
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300uL of 10mM solution |
50 EUR
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