eIF4E/eIF4G Interaction Inhibitor
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eIF4E/eIF4G Interaction Inhibitor

2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid

KD for eIF4E binding is estimated of 25 µM 

OTAVAchemicals Catalogue Number: 7070707011
CAS Registry Number: 315706-13-9

Purity: 98% (HPLC)

Ref.: Cell 2007, 128, 2, 257 – 267 Virology 2013, 444,171 – 180

Abstract: 4EGI-1 binds eIF4E, disrupts association of translation initiation factors into eIF4E/eIF4G complex and inhibits cap-dependent translation but not initiation factor independent translation. 4EGI-1 inhibits translation driven by poliovirus IRES, vesicular stomatitis virus and Sindbis virus despite cleavage of eIF4G by picornavirus proteases, suggesting that this molecule may affect other steps in protein synthesis unrelated to cap recognition by eIF4E.
DOI: 10.1016/j.cell.2006.11.046 10.1016/j.virol.2013.06.008


Price info:
1 MG 35 EUR
5 MG 80 EUR
10 MG 120 EUR
300uL of 10mM solution

50 EUR