N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride

Inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase IC50 = 29 pM 

OTAVAchemicals Catalogue Number: 7020540711
CAS Registry Number: 153436-54-5
Purity: 95%+ (HPLC)

Ref.: Science 1994, 265, 5175, 1093 – 1095

Abstract: PD 153035 rapidly suppressed autophosphorylation of the EGF receptor at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells and selectively blocked EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. 

DOI: 10.1126/science.8066447