Histone Deacetylase Inhibitor VI
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Histone Deacetylase Inhibitor VI


HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM)


OTAVAchemicals Catalogue Number: 7070707016
CAS Registry Number: 926908-04-5
Purity: 98% (HPLC)

Ref.: Kim et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio)heptanomide, a novel histone deacetylase inhibitor. Biochemical and Biophysical Research Communications (2007), 356, 233-238

Abstract: A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.

DOI: 10.1016/j.bbrc.2007.02.126

Price info:
1 MG 39 EUR
5 MG 79 EUR
10 MG 99 EUR
300uL of 10mM solution 59 EUR