• HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM)
OTAVAchemicals Catalogue Number: 7070707016
CAS Registry Number: 926908-04-5
Purity: 95%+ (HPLC)
Ref.: Kim et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio)heptanomide, a novel histone deacetylase inhibitor. Biochemical and Biophysical Research Communications (2007), 356, 233-238
Abstract: N-Hydroxy-7-(2-naphthylthio)heptanamide (HNHA) is a histone deacetylase (HDAC) inhibitor with antitumor activity both in vitro and in vivo. The compound inhibited HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080) in vitro. Treatment of cells with HNHA elicited histone hyperacetylation leading to an up-regulation of p21 transcription, cell cycle arrest, and an inhibition of HT1080 cell invasion. Moreover, HNHA effectively inhibited the growth of tumor tissue in a mouse xenograph assay in vivo. Together, these data demonstrate that this novel HDAC inhibitor could be developed as a potential antitumor agent targeting HDAC.