• Cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 µM and 5.6 µM for Cdk4/D1 and Cdk6/D1, respectively)
OTAVAchemicals Catalogue Number: 1112092
CAS Registry Number: 359886-84-3
Purity: 95%+ (HPLC)
Ref.: Soni et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. Journal of the National Cancer Institute (2001), 93, 436-446
Abstract: Like p16, the natural inhibitor of Cdk4, CINK4 inhibits Cdk4 activity in vitro and slows tumor growth in vivo.