methyl N-[[4-[[2-amino-5-(2-thienyl)phenyl]carbamoyl]phenyl]methyl]carbamate

Histone deacetylase HDAC1 inhibitor IC50 = 6 nM, HCT-116 mouse xenograft model GI50 = 100 nM

OTAVAchemicals Catalogue Number: 7070707089
CAS Registry Number: 1013330-84-1
Purity: 98%

Ref.: Witter et al. Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters (2008), 18, 726-731

Abstract: Selective HDAC1/2 inhibitor, exhibiting selectivity over class II HDACs 3–8. Histone deacetylases are considered promising targets for cancer epigenetic therapy

DOI: 10.1016/j.bmcl.2007.11.047