4-acetamido-N-[2-amino-5-(2-thienyl)phenyl]benzamide

Histone deacetylase HDAC1/2 selective inhibitor, HDAC1 IC50 = 0.007 µM, HDAC2 IC50 = 0.049 µM,

HCT116 proliferation assay GI50 = 0.11 µM 

OTAVAchemicals Catalogue Number: 7070707091
CAS Registry Number: 849234-64-6
Purity: 97%

Ref.:  Bioorg. Med. Chem. Lett. 2008, 18, 973–978

Abstract: Selective HDAC1/2 inhibitor, exhibiting selectivity over class II HDACs 3–8. Histone deacetylases are considered promising targets for cancer epigenetic therapy. Elimination of HIV-1 latently infected cells by gnidimacrin - a protein kinase C (PKC) agonist was potentiated by TPB in cell models by 2–3 folds

DOI: 10.1016/j.bmcl.2007.12.031