8-hydroxyquinoline-5-carboxylic acid

IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of ß-thalassemia by a-globin downregulation

Chemical Formula: C10H7NO3

Molecular Weight: 189.2

OTAVAchemicals Catalogue Number: 3476873

CAS Registry Number: 5852-78-8

Purity: 96%+ (HPLC)

Ref.: Haematologica, 102(3), e80-e84 (2017)

Abstract: IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. 

DOI: 10.3324/haematol.2016.155655