Home > PRODUCTS > Biochemicals > Aloesone

Diversity screening library discount

Newsletter Subscription

Stay updated with our new products and services. You can unsubscribe at any time.



                                        An inhibitor of the production of nitric oxide (NO) 

Chemical Formula: C13H12O4

Molecular Weight: 232.2382

OTAVAchemicals Catalogue Number: 3699690

CAS Registry Number: 40738-40-7

Purity: 95% (HPLC)


Ref.: Liu, Q., Mu, Y., An, Q., Xun, J., Ma, J., Wu, W., … Huang, X. (2019). Total synthesis and anti-inflammatory evaluation of violacin A and its analogues. Bioorganic Chemistry, 103420.


Abstract: A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A as well as the preparation of thirty analogues of this lead from commercially available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkatamaran rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid the elimination of the hemiacetal hydroxyl at C2. In addition, all synthetic compounds were screened for anti-inflammatory activity against nitric oxide (NO) production using lipopolysaccharide (LPS)-induced Raw264.7 cells. A range of violacin A derivatives 11b, 11d, 11f, 12e, 12g, 13g, 17d-g exhibited stronger anti-inflammatory effect than that of violacin A. Notably, halogeno-benzyloxy substituent at C-7 were favourable for anti-inflammatory activities of violacin A derivatives. Additionally, Western blot results indicated halogeno-benzyloxy derivatives inhibited pro-inflammatory cytokines releases correlated with the suppression of NF-ƒÛB signaling pathway.

DOI: 10.1016/j.bioorg.2019.103420


Price info:
1 MG 79 EUR
5 MG 129 EUR
10 MG 199 EUR
300uL of 10mM solution

104 EUR