Ilomastat; Galardin
Home > PRODUCTS > Biochemicals > Ilomastat; Galardin

Newsletter Subscription

Stay updated with our new products and services. You can unsubscribe at any time.

Ilomastat; Galardin

N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

A potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8;
and Ki = 200 pM for MMP-9). Prevents the release of TNF-a in vivo and in vitro and abrogates endotoxin-induced lethality in mice.

Chemical Formula: C20H28N4O4

Molecular Weight: 388.4706

OTAVAchemicals Catalogue Number: 7070707140

CAS Registry Number: 142880-36-2

Purity: 97% (HPLC)

Ref.: Metalloprotease Inhibitors GM6001 and TAPI-0 Inhibit the Obligate Intracellular Human Pathogen Chlamydia trachomatis by Targeting Peptide Deformylase of the Bacterium*Amit Balakrishnan, Bhairavi Pate , Stephan A. Sieber at all. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 281, NO. 24, pp. 16691–16699.

Abstract: To further assess the cytoprotective effect of ilomastat, primary cardiomyocytes isolated from neonatal rats were subjected to 240min simulated ischemia followed by 120min simulated reperfusion in the  presence of ilomastat (5nM-5µM). Ilomastat at 500nM and 5µM significantly increased cell viability when compared to vehicle treated group. To assess the in situ MMP-2 inhibitory effect of ilomastat, in separate experiments in situ zymography was performed in cardiomyocytes. The cytoprotective concentration of ilomastat (500nM) showed a moderate (approximately 25%) inhibition of intracellular MMP-2 in ischemic/reperfused cardiomyocytes. In these cells, MMP-2 immunostaining showed a 90% colocalization with the in situ gelatinolytic activity.


Price info:
1 MG 79 EUR
5 MG 129 EUR
10 MG 199 EUR
300uL of 10mM solution

104 EUR