4-Nitro-benzoic acid 4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)-4H-pyran-3-yl ester

apelin receptor (APJ) antagonist 

Chemical Formula: C17H11N3O6S

Molecular Weight: 385.4

OTAVAchemicals Catalogue Number:   1024331

CAS Registry Number:  877636-42-5

Purity: 98%

Ref.: Bioorg Med Chem Lett . 2012 Nov 1;22(21):6656-60

Abstract: ML 221 is an apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM.

DOI: 10.1016/j.bmcl.2012.08.105