3-(benzofuran-3-yl)-4-(5-bromo-1-methyl-indol-3-yl)pyrrole-2,5-dione

GSK-3ß inhibitor, Ki = 4.6 nM

Chemical Formula: C21H13BrN2O3

Molecular Weight: 421.3

OTAVAchemicals Catalogue Number:  7070707084

CAS Registry Number:  941575-71-9

Purity:  95%

Ref.: . J. Am. Chem. Soc. 2007, 129, 8328–8332

Abstract:  BIP-135 as a specific inhibitor of the GSK-3ß protein kinase was used for the treatment of mood and neurodegenerative disorders, to induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth as well as a stimulator of steroidogenesis

DOI: 10.1021/ja068969w