2-(6-methyl-2-pyridyl)-N-(4-pyridyl)quinazolin-4-amine

Potent and selective ALK5 inhibitors over p38MAP kinase. ALK5 binding IC50 = 0.022 µM,

p38alpha binding IC50 = 6.72 µM, TGF-ß cellular assay IC50 = 0.095 µM 

Chemical Formula: C19H15N5

Molecular Weight: 313.4

OTAVAchemicals Catalogue Number:  7070707105

CAS Registry Number:  733806-89-8

Purity:  97%

Ref.: Bioorg. Med. Chem. Lett. 2009, 19, 2277–2281

Abstract:  Potent and selective human ALK5 kinase inhibitors over p38MAP kinase. It exhibited also in vivo activity in an acute rat model of DMN-induced liver fibrosis when administered orally at 5 mg/kg (bid)

DOI: 10.1016/j.bmcl.2009.02.087