N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-acetamide

PIK93 inhibits poliovirus (PV) and coxsackievirus B3 (CVB3) viral RNA production and virus replication. PIK93 also prevents translation mediated by internal ribosome entry site (IRES).

PIK93 blocks ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi

OTAVAchemicals Catalogue Number: 7070707029

CAS Registry Number: 593960-11-3

Purity: 95%+ (HPLC)

Ref.: Knight, Z.A., Gonzalez, B., Feldman, M.E., et al. A pharmacological map of the PI3-K family defines a role for p110a in insulin signaling. Cell 125(4), 733-747 (2006)

Abstract: PIK-93 inhibits of replication of enterovirus including polio and hepatitis C. PIK93 is a potent, selective, ATP competitive and reversible inhibitor of PI3K? and PI4KIIIЯ (IC50 = 16 nM and 19 nM, respectively). Also PIK93 moderately inhibits other members of the family including p110d, PI 3-KC2Я, hsVPS34, ATM, p110Я and PI 4-KIIIa (IC50 = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 µM, respectively).

DOI: 10.1016/j.cell.2006.03.035

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