ethyl 4-[5-[(2-ethoxypyrimidin-5-yl)methyl]-2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-pyrimidin-1-yl]benzoate

Gprotein-coupled receptor 40 (GPR40; free fatty acid receptor 1; FFAR1) antagonist pIC50 = 5.99, oxytocin receptor antagonist pIC50 = 6.9 

Chemical Formula: C27H25FN4O4S

Molecular Weight: 520.6

OTAVAchemicals Catalogue Number: 7070707009 

CAS Registry Number: 306974-70-9

Purity: 98%+ (HPLC)

Ref.: Brit. J. Pharm. 2006, 148, 5, 619 – 628

Abstract: GW1100 dose dependently inhibited GPR40-mediated Ca2+ elevations stimulated by GW9508 and linoleic acid. GW1100 had no effect on the GPR120-mediated stimulation of intracellular Ca2+ release

DOI: 10.1038/sj.bjp.0706770