Kinesin-like protein 1 Inhibitor
Potent inhibitor of Kinesin-like protein 1 with activity in the ATPase assay of 1.7±0.4 μM and the MPM-2 cytoblot assay of 0.48±0.13 μM.
OTAVAchemicals Catalogue Number: 7112880116
CAS Registry Number: N/A
Ref.: A. B. Pinkerton et al. Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors. Bioorg. Med. Chem. Lett. 17 (2007) 3562–3569.
Abstract: We have identiﬁed and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.