6-Methyl-4-(3-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

calcium channel blocker; induces apoptotic cell death in triple negative breast cancer (TNBC) cells 

Chemical Formula: C14H15N3O5

Molecular Weight: 305.3

OTAVAchemicals Catalogue Number:   0111850003

CAS Registry Number:  110448-29-8

Purity: >95%

Ref.: Journal of Biological Chemistry (2012), 287(39), 32881-32896

Abstract: Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. Nifetepimine induces apoptotic cell death in triple negative breast cancer (TNBC) cells by stimulation of cross-talk between ER stress and the MEK/ERK pathway.

DOI: 10.1074/jbc.M112.357889