N,4-dimethyl-5-[2-(3-methylsulfonylanilino)pyrimidin-4-yl]thiazol-2-amine

Selective CDK2 and CDK9 inhibitor

Chemical Formula: C16H17N5O2S2

Molecular Weight: 375.5

OTAVAchemicals Catalogue Number:  3485491

CAS Registry Number:  870780-40-8

Purity:  95%

Ref.: Chemistry & Biology 2010, 17, 1111–1121

Abstract:  CAS# 870780-40-8 inhibits a family of cyclin-dependent kinases (CDKs) which are key cell cycle regulators and some of them also have regulatory functions in mRNA transcription. Selectively inhibited CDK2 and CDK9 with Ki 1.6nM and 0.29nM, respectively

DOI: 10.1016/j.chembiol.2010.07.016